In vitro model of Treponema pallidum invasiveness
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چکیده
منابع مشابه
In vitro model of Treponema pallidum invasiveness.
The purpose of this investigation was to develop an in vitro model with which invasion of tissues by pathogenic Treponema pallidum could be studied. Double-sided culture chambers were created by mounting abdominal walls excised from mice between two halves of small dialysis cells. The integrity of tissue barriers was confirmed by dye exclusion. T. pallidum subsp. pallidum, including intrinsical...
متن کاملShape of Treponema pallidum.
Treponema pallidum was found to be not helical, but a flat wave twisted into one to five different planes per cell.
متن کاملMucopolysaccharidase of Treponema pallidum.
Treponema pallidum (Nichols strain) exhibited mucopolysaccharidase activity. Acidic mucopolysaccharides were broken down more rapidly by viable treponemes than by heat-inactivated treponemes or membrane filtrates of treponemal suspensions. Ouchterlony immunodiffusion demonstrated the occurrence of antibodies to the hyaluronidase-like enzyme within syphilitic sera. After intratesticular inoculat...
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Ultrathin sections of a rabbit scrotal syphiloma were examined by electron microscopy. Treponemes were observed in the endo-, peri-, and epineurium of the nerve fibre. The significance of these findings, in that infection may be transmitted via the nerve fibres and pain reduced by damage to the afferent fibres, are discussed.
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Smith and Israel (1967a, 1967b, 1968) and Goldman and associates (Goldman and Girard, 1968; Girard, Goldman, Baumstark, and Stickle, 1967) have recently reported that spiral organisms, some of which are motile, can be demonstrated in the aqueous humour (AH), cerebrospinal fluid (CSF), and tissues of adequately treated syphilitic patients. Most of these organisms are morphologically indistinguis...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1989
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.57.8.2267-2271.1989